Research Focus:Antiviral drug pharmacokinetic-pharmacodynamic relationships in humansNew assays for drug/metabolite quantification in unique compartments in humansUsing drug concentrations to assess adherence to antiviral therapies
Research Focus:Biophysical characterization of therapeutic macromoleculesMechanisms of transcriptional regulationThermodynamics of protein-protein and protein-DNA interactions
ProfessorToxicology Graduate Program Director, T32 Training Program in Molecular and Systems Toxicology Director, Colorado Center for Nanomedicine and Nanosafety Co-Director
Department of Pharmaceutical Sciences
Research Focus:Bladder CancerChronic kidney disease of unknown origin (CKDu)Inflammation and immune responses to particulatesMast cells and allergyNanomedicine and Nanosafety
Research Focus:CAR T and engineered T cell therapies of autoimmune diseasesMechanisms of T cell mediated metal hypersensitivitiesMechanisms of T cell recognition of autoantigens in Type 1 diabetes and RARedox signaling and drug design in the immune diseases and infectious diseases
Research Focus:Autoantigen discovery in autoimmune diseasesMass spectrometryPathogenesis of Type 1 DiabetesPost-translational modificationsT cell immunology
Research Focus:Mechanisms of alcoholic liver diseaseMetabolic dysregulation of liver and kidney functionRegulatory nature of sirtuin activity and protein acetylationUtilizing mass spectrometry to investigate proteomics & post-translational modifications
ProfessorProfessor, Director of Innovation and Commercialization, Director of Entrepreneurship Education, SPARK/REACH Program
Department of Pharmaceutical Sciences
Research Focus:Discovery and Translation of Novel Treatment Approaches to Kidney DiseasesIn Vivo and In Vitro Drug Metabolism and Transport in KidneyNephrotoxicity / BiomarkersPharmacokinetics/Pharmacodynamics/Pharmacogenomics
Colorado Center for Nanomedicine and Nanosafety Co-Director and Co-founderProfessor of Pharmaceutical Sciences, Ophthalmology, and Bioengineering
Department of Pharmaceutical Sciences
Research Focus:Nanomedicines for drug delivery gene delivery and imagingNovel drug delivery systems: Nanoparticles microparticles and implants.Novel therapies for diabetic retinopathy macular degeneration and cancers.Ocular respiratory and brain drug discovery delivery and development
ProfessorDirector CU AMC Center for Drug Discovery, Co-Director, Drug Discovery and Development Shared Resource (D3SR)
Department of Pharmaceutical Sciences
Research Focus:Drug DesignDrug Mechanism(s) of ActionHTS/HCS Drug DiscoveryIn vitro and In vivo Pharmacokinetics and ToxicologyIn vitro and In vivo PharmacologyMolecular and Cancer BiologyOrganic and Medicinal Chemistry
Professor, Pharmaceutical Sciences Graduate Program Associate Director
Department of Pharmaceutical Sciences
Research Focus:2D NMR spectroscopy of antibody therapeuticsBiophysical characterization of protein vaccine stability and aggregationStructure stability and aggregation of protein drug substances and drug productsStructure-function-disease analysis of dystrophin and muscular dystrophy
Assistant ProfessorToxicology Graduate Program Associate Director
Department of Pharmaceutical Sciences
Research Focus:Complement-mediated tissue damageExtracellular vesicles and organ-organ crosstalkImmunotherapy and natural immunosuppressionInnate immunity and chronic liver diseases
Associate Dean for Research and Graduate Studies, Professor
Department of Pharmaceutical Sciences
Research Focus:Environmental causes of neuronal injuryMitochondrial (dys)function and oxidative stress in epilepsy and neurodegenerationNeuroinflammation and redox signalingRedox-based small molecule therapeutics